Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
cltr2_human | 96 | 2.62x62 | TM2 | D => IlefsTer33 | frameshift | 1.649e-05 | 2 | 121320 | 0 | None | None | |
cltr2_human | 135 | 3.49x49 | TM3 | V => CysfsTer37 | frameshift | 8.238e-06 | 1 | 121388 | 0 | None | None | SodiumPocket MicroSwitch |
cltr2_human | 156 | 4.43x43 | TM4 | W => Ter | stop gained | 8.24e-06 | 1 | 121358 | 0 | None | None | |
cltr2_human | 161 | 4.48x48 | TM4 | I => AspfsTer19 | frameshift | 4.944e-05 | 6 | 121348 | 0 | None | None | |
cltr2_human | 203 | 5.40x41 | TM5 | Y => Ter | stop gained | 8.24e-06 | 1 | 121362 | 0 | None | None | |
cltr2_human | 206 | 5.43x44 | TM5 | L => TrpfsTer18 | frameshift | 1.648e-05 | 2 | 121370 | 0 | None | None | |
cltr2_human | 293 | 7.41x40 | TM7 | L => Ter | stop gained | 8.299e-06 | 1 | 120490 | 0 | None | None | |
cltr2_human | 306 | 7.54x54 | TM7 | Y => Ter | stop gained | 1.708e-05 | 2 | 117104 | 0 | None | None | |
cltr2_human | 11 | N-term | S => P | missense | 8.268e-06 | 1 | 120954 | 0 | 0.12 | 0.001 | ||
cltr2_human | 14 | N-term | V => I | missense | 4.127e-05 | 5 | 121156 | 0 | 1.0 | 0.0 | ||
cltr2_human | 17 | N-term | M => T | missense | 1.649e-05 | 2 | 121268 | 0 | 0.03 | 0.01 | ||
cltr2_human | 19 | N-term | P => L | missense | 0.0001319 | 16 | 121294 | 0 | 0.43 | 0.001 | ||
cltr2_human | 22 | N-term | T => N | missense | 8.243e-06 | 1 | 121316 | 0 | 0.57 | 0.004 | ||
cltr2_human | 36 | 1.30x30 | TM1 | F => L | missense | 0.0001071 | 13 | 121344 | 0 | 0.0 | 0.998 | |
cltr2_human | 39 | 1.33x33 | TM1 | E => Q | missense | 0.002918 | 354 | 121336 | 5 | 0.72 | 0.005 | |
cltr2_human | 42 | 1.36x36 | TM1 | P => S | missense | 8.241e-06 | 1 | 121342 | 0 | 0.51 | 1.0 | |
cltr2_human | 42 | 1.36x36 | TM1 | P => L | missense | 8.241e-06 | 1 | 121338 | 0 | 0.0 | 1.0 | |
cltr2_human | 44 | 1.38x38 | TM1 | V => A | missense | 3.296e-05 | 4 | 121344 | 0 | 0.27 | 0.006 | |
cltr2_human | 46 | 1.40x40 | TM1 | L => P | missense | 8.241e-06 | 1 | 121348 | 0 | 0.02 | 0.994 | |
cltr2_human | 48 | 1.42x42 | TM1 | I => L | missense | 8.24e-06 | 1 | 121354 | 0 | 0.0 | 0.591 | |
cltr2_human | 50 | 1.44x44 | TM1 | F => V | missense | 0.004738 | 575 | 121352 | 4 | 1.0 | 0.0 | |
cltr2_human | 58 | 1.52x52 | TM1 | L => S | missense | 1.648e-05 | 2 | 121366 | 0 | 0.0 | 0.588 | |
cltr2_human | 61 | 1.55x55 | TM1 | Y => F | missense | 8.24e-06 | 1 | 121366 | 0 | 0.29 | 0.083 | |
cltr2_human | 65 | 1.59x59 | TM1 | Q => P | missense | 8.24e-06 | 1 | 121358 | 0 | 0.0 | 0.912 | |
cltr2_human | 66 | 1.60x60 | TM1 | P => S | missense | 6.592e-05 | 8 | 121352 | 0 | 0.61 | 0.054 | |
cltr2_human | 66 | 1.60x60 | TM1 | P => L | missense | 9.889e-05 | 12 | 121352 | 0 | 0.06 | 0.052 | |
cltr2_human | 67 | ICL1 | Y => H | missense | 7.417e-05 | 9 | 121348 | 0 | 0.14 | 0.026 | ||
cltr2_human | 70 | ICL1 | S => F | missense | 8.241e-06 | 1 | 121348 | 0 | 0.01 | 0.83 | ||
cltr2_human | 74 | 2.40x40 | TM2 | N => S | missense | 8.241e-06 | 1 | 121340 | 0 | 0.01 | 0.974 | |
cltr2_human | 75 | 2.41x41 | TM2 | V => I | missense | 8.242e-06 | 1 | 121336 | 0 | 0.79 | 0.012 | |
cltr2_human | 77 | 2.43x43 | TM2 | M => L | missense | 8.242e-06 | 1 | 121336 | 0 | 0.06 | 0.583 | |
cltr2_human | 79 | 2.45x45 | TM2 | N => S | missense | 8.242e-06 | 1 | 121328 | 0 | 0.0 | 1.0 | |
cltr2_human | 80 | 2.46x46 | TM2 | L => V | missense | 8.242e-06 | 1 | 121326 | 0 | 0.0 | 1.0 | |
cltr2_human | 90 | 2.56x56 | TM2 | T => M | missense | 0.0001566 | 19 | 121332 | 0 | 0.01 | 0.998 | |
cltr2_human | 92 | 2.58x58 | TM2 | P => R | missense | 8.242e-06 | 1 | 121326 | 0 | 0.0 | 1.0 | |
cltr2_human | 95 | 2.61x61 | TM2 | A => T | missense | 8.243e-06 | 1 | 121320 | 0 | 0.03 | 0.828 | |
cltr2_human | 95 | 2.61x61 | TM2 | A => V | missense | 8.243e-06 | 1 | 121318 | 0 | 1.0 | 0.058 | |
cltr2_human | 97 | 2.63x63 | TM2 | Y => N | missense | 8.243e-05 | 10 | 121322 | 0 | 0.0 | 1.0 | |
cltr2_human | 100 | 2.66x66 | TM2 | R => I | missense | 8.242e-06 | 1 | 121334 | 0 | 0.09 | 0.438 | |
cltr2_human | 101 | 2.67x67 | TM2 | G => V | missense | 8.243e-06 | 1 | 121314 | 0 | 0.01 | 0.954 | |
cltr2_human | 103 | 23.49x49 | ECL1 | N => D | missense | 8.243e-06 | 1 | 121320 | 0 | 0.45 | 0.009 | |
cltr2_human | 103 | 23.49x49 | ECL1 | N => S | missense | 0.005053 | 613 | 121322 | 5 | 0.27 | 0.048 | |
cltr2_human | 103 | 23.49x49 | ECL1 | N => T | missense | 8.243e-06 | 1 | 121322 | 0 | 0.17 | 0.243 | |
cltr2_human | 108 | 3.22x22 | TM3 | D => H | missense | 8.242e-06 | 1 | 121326 | 0 | 0.0 | 0.923 | |
cltr2_human | 109 | 3.23x23 | TM3 | L => P | missense | 2.473e-05 | 3 | 121334 | 0 | 0.01 | 0.882 | |
cltr2_human | 114 | 3.28x28 | TM3 | M => I | missense | 3.296e-05 | 4 | 121348 | 0 | 0.68 | 0.207 | |
cltr2_human | 116 | 3.30x30 | TM3 | Y => H | missense | 8.24e-06 | 1 | 121356 | 0 | 0.0 | 0.993 | |
cltr2_human | 117 | 3.31x31 | TM3 | S => P | missense | 8.24e-06 | 1 | 121356 | 0 | 0.01 | 0.989 | |
cltr2_human | 118 | 3.32x32 | TM3 | L => F | missense | 8.24e-06 | 1 | 121362 | 0 | 0.14 | 0.01 | |
cltr2_human | 119 | 3.33x33 | TM3 | Y => H | missense | 8.24e-06 | 1 | 121362 | 0 | 0.02 | 0.712 | LB (polar (hydrogen bond)) |
cltr2_human | 122 | 3.36x36 | TM3 | M => T | missense | 3.296e-05 | 4 | 121376 | 0 | 0.0 | 0.999 | |
cltr2_human | 123 | 3.37x37 | TM3 | Y => H | missense | 4.119e-05 | 5 | 121380 | 0 | 0.0 | 0.995 | LB (hydrophobic, Van der Waals, aromatic (face-to-edge)) |
cltr2_human | 124 | 3.38x38 | TM3 | S => G | missense | 1.648e-05 | 2 | 121380 | 0 | 0.03 | 0.034 | |
cltr2_human | 128 | 3.42x42 | TM3 | F => L | missense | 2.471e-05 | 3 | 121390 | 0 | 0.04 | 1.0 | |
cltr2_human | 131 | 3.45x45 | TM3 | V => M | missense | 6.59e-05 | 8 | 121390 | 0 | 0.04 | 0.972 | |
cltr2_human | 132 | 3.46x46 | TM3 | L => R | missense | 2.471e-05 | 3 | 121388 | 0 | 0.0 | 0.998 | |
cltr2_human | 136 | 3.50x50 | TM3 | R => C | missense | 1.648e-05 | 2 | 121392 | 0 | 0.02 | 0.998 | SodiumPocket MicroSwitch GP (contact) |
cltr2_human | 136 | 3.50x50 | TM3 | R => H | missense | 1.648e-05 | 2 | 121386 | 0 | 0.01 | 0.696 | SodiumPocket MicroSwitch GP (contact) |
cltr2_human | 136 | 3.50x50 | TM3 | R => P | missense | 8.238e-06 | 1 | 121386 | 0 | 0.0 | 0.998 | SodiumPocket MicroSwitch GP (contact) |
cltr2_human | 137 | 3.51x51 | TM3 | F => S | missense | 0.0002389 | 29 | 121390 | 0 | 0.0 | 0.971 | |
cltr2_human | 139 | 3.53x53 | TM3 | A => S | missense | 8.238e-06 | 1 | 121388 | 0 | 0.0 | 1.0 | GP (contact) |
cltr2_human | 139 | 3.53x53 | TM3 | A => V | missense | 8.238e-06 | 1 | 121386 | 0 | 0.02 | 1.0 | GP (contact) |
cltr2_human | 140 | 3.54x54 | TM3 | M => V | missense | 1.648e-05 | 2 | 121386 | 0 | 0.05 | 0.0 | GP (contact) |
cltr2_human | 140 | 3.54x54 | TM3 | M => T | missense | 1.648e-05 | 2 | 121384 | 0 | 0.49 | 0.0 | GP (contact) |
cltr2_human | 145 | 34.52x52 | ICL2 | R => W | missense | 6.591e-05 | 8 | 121374 | 0 | 0.03 | 0.959 | GP (contact) |
cltr2_human | 145 | 34.52x52 | ICL2 | R => Q | missense | 0.0001977 | 24 | 121378 | 0 | 0.91 | 0.098 | GP (contact) |
cltr2_human | 146 | 34.53x53 | ICL2 | L => F | missense | 8.239e-06 | 1 | 121372 | 0 | 0.7 | 0.009 | GP (contact) |
cltr2_human | 153 | 4.40x40 | TM4 | R => K | missense | 8.24e-06 | 1 | 121358 | 0 | 1.0 | 0.014 | |
cltr2_human | 154 | 4.41x41 | TM4 | S => N | missense | 0.001599 | 194 | 121360 | 0 | 0.64 | 0.003 | |
cltr2_human | 161 | 4.48x48 | TM4 | I => F | missense | 8.241e-06 | 1 | 121344 | 0 | 0.3 | 0.009 | |
cltr2_human | 166 | 4.53x53 | TM4 | I => F | missense | 8.241e-06 | 1 | 121340 | 0 | 0.0 | 0.529 | LB (hydrophobic, Van der Waals) |
cltr2_human | 166 | 4.53x53 | TM4 | I => T | missense | 5.769e-05 | 7 | 121344 | 0 | 0.03 | 0.024 | LB (hydrophobic, Van der Waals) |
cltr2_human | 168 | 4.55x55 | TM4 | A => P | missense | 8.242e-06 | 1 | 121332 | 0 | 0.09 | 0.966 | |
cltr2_human | 171 | 4.58x59 | TM4 | I => V | missense | 8.241e-06 | 1 | 121338 | 0 | 0.25 | 0.002 | |
cltr2_human | 171 | 4.58x59 | TM4 | I => T | missense | 8.241e-06 | 1 | 121338 | 0 | 0.56 | 0.002 | |
cltr2_human | 172 | 4.59x60 | TM4 | M => K | missense | 8.242e-06 | 1 | 121336 | 0 | 0.19 | 0.08 | |
cltr2_human | 174 | 4.61x62 | TM4 | L => R | missense | 2.472e-05 | 3 | 121338 | 0 | 0.0 | 0.999 | |
cltr2_human | 176 | 4.63x64 | TM4 | S => T | missense | 1.648e-05 | 2 | 121342 | 0 | 0.5 | 0.007 | |
cltr2_human | 177 | ECL2 | G => S | missense | 8.241e-06 | 1 | 121340 | 0 | 0.06 | 0.639 | ||
cltr2_human | 201 | 5.38x39 | TM5 | M => V | missense | 0.01701 | 2064 | 121362 | 28 | 0.05 | 0.345 | LB (hydrophobic, Van der Waals) |
cltr2_human | 202 | 5.39x40 | TM5 | N => K | missense | 8.24e-06 | 1 | 121358 | 0 | 0.0 | 1.0 | LB (Van der Waals) |
cltr2_human | 203 | 5.40x41 | TM5 | Y => C | missense | 2.472e-05 | 3 | 121360 | 0 | 0.02 | 0.937 | |
cltr2_human | 205 | 5.42x43 | TM5 | A => T | missense | 8.239e-06 | 1 | 121370 | 0 | 0.06 | 0.309 | LB (hydrophobic, Van der Waals) |
cltr2_human | 209 | 5.46x461 | TM5 | G => D | missense | 8.24e-06 | 1 | 121366 | 0 | 0.0 | 1.0 | LB (Van der Waals) |
cltr2_human | 210 | 5.47x47 | TM5 | C => W | missense | 2.472e-05 | 3 | 121376 | 0 | 0.0 | 0.001 | SodiumPocket MicroSwitch |
cltr2_human | 211 | 5.48x48 | TM5 | L => Q | missense | 2.472e-05 | 3 | 121378 | 0 | 0.0 | 0.83 | |
cltr2_human | 216 | 5.53x53 | TM5 | T => I | missense | 8.238e-06 | 1 | 121382 | 0 | 0.52 | 0.024 | |
cltr2_human | 218 | 5.55x55 | TM5 | S => R | missense | 2.472e-05 | 3 | 121378 | 0 | 0.11 | 0.721 | |
cltr2_human | 220 | 5.57x57 | TM5 | C => Y | missense | 0.0001895 | 23 | 121370 | 0 | 0.0 | 0.995 | |
cltr2_human | 225 | 5.62x62 | TM5 | I => V | missense | 8.24e-06 | 1 | 121352 | 0 | 0.17 | 0.21 | |
cltr2_human | 225 | 5.62x62 | TM5 | I => N | missense | 8.241e-06 | 1 | 121348 | 0 | 0.0 | 0.983 | |
cltr2_human | 226 | 5.63x63 | TM5 | R => W | missense | 2.472e-05 | 3 | 121342 | 0 | 0.05 | 0.998 | |
cltr2_human | 226 | 5.63x63 | TM5 | R => Q | missense | 8.242e-06 | 1 | 121332 | 0 | 0.02 | 0.962 | |
cltr2_human | 227 | 5.64x64 | TM5 | V => F | missense | 8.241e-06 | 1 | 121340 | 0 | 0.0 | 0.328 | GP (contact) |
cltr2_human | 227 | 5.64x64 | TM5 | V => D | missense | 8.241e-06 | 1 | 121338 | 0 | 0.01 | 0.291 | GP (contact) |
cltr2_human | 232 | ICL3 | E => Q | missense | 3.297e-05 | 4 | 121310 | 0 | 0.27 | 0.529 | ||
cltr2_human | 236 | 6.24x25 | TM6 | S => L | missense | 0.009391 | 1139 | 121280 | 57 | 0.23 | 0.01 | GP (contact) |
cltr2_human | 239 | 6.27x28 | TM6 | R => W | missense | 3.299e-05 | 4 | 121254 | 0 | 0.0 | 0.804 | GP (contact) |
cltr2_human | 239 | 6.27x28 | TM6 | R => Q | missense | 8.247e-05 | 10 | 121258 | 0 | 0.43 | 0.016 | GP (contact) |
cltr2_human | 242 | 6.30x31 | TM6 | H => Q | missense | 0.003051 | 370 | 121272 | 8 | 0.06 | 0.281 | |
cltr2_human | 249 | 6.37x38 | TM6 | I => V | missense | 9.895e-05 | 12 | 121270 | 0 | 0.12 | 0.016 | |
cltr2_human | 251 | 6.39x40 | TM6 | I => V | missense | 0.0002886 | 35 | 121274 | 1 | 0.16 | 0.759 | GP (contact) |
cltr2_human | 253 | 6.41x42 | TM6 | L => S | missense | 8.245e-06 | 1 | 121280 | 0 | 0.0 | 0.971 | |
cltr2_human | 259 | 6.47x47 | TM6 | C => G | missense | 4.122e-05 | 5 | 121304 | 0 | 0.01 | 1.0 | |
cltr2_human | 263 | 6.51x51 | TM6 | Y => C | missense | 0.0002885 | 35 | 121328 | 0 | 0.0 | 1.0 | |
cltr2_human | 264 | 6.52x52 | TM6 | H => R | missense | 8.242e-06 | 1 | 121326 | 0 | 0.0 | 1.0 | |
cltr2_human | 268 | 6.56x56 | TM6 | T => A | missense | 8.242e-06 | 1 | 121332 | 0 | 0.01 | 1.0 | |
cltr2_human | 269 | 6.57x57 | TM6 | V => I | missense | 4.944e-05 | 6 | 121348 | 0 | 0.59 | 0.001 | |
cltr2_human | 272 | 6.60x60 | TM6 | T => M | missense | 0.0001401 | 17 | 121348 | 0 | 0.11 | 0.0 | |
cltr2_human | 278 | ECL3 | L => I | missense | 0.00473 | 574 | 121356 | 4 | 0.22 | 0.0 | ||
cltr2_human | 281 | 7.29x28 | TM7 | D => E | missense | 0.0005605 | 68 | 121328 | 3 | 1.0 | 0.003 | |
cltr2_human | 282 | 7.30x29 | TM7 | R => G | missense | 2.473e-05 | 3 | 121326 | 0 | 0.41 | 0.001 | |
cltr2_human | 288 | 7.36x35 | TM7 | V => I | missense | 1.652e-05 | 2 | 121096 | 0 | 0.08 | 0.2 | |
cltr2_human | 292 | 7.40x39 | TM7 | A => G | missense | 0.0001575 | 19 | 120610 | 0 | 0.04 | 0.226 | |
cltr2_human | 295 | 7.43x42 | TM7 | A => V | missense | 1.665e-05 | 2 | 120086 | 0 | 0.05 | 0.21 | |
cltr2_human | 298 | 7.46x46 | TM7 | A => T | missense | 8.36e-06 | 1 | 119620 | 0 | 0.29 | 0.0 | |
cltr2_human | 299 | 7.47x47 | TM7 | C => F | missense | 0.0004358 | 52 | 119330 | 0 | 0.0 | 1.0 | |
cltr2_human | 299 | 7.47x47 | TM7 | C => Y | missense | 8.38e-06 | 1 | 119330 | 0 | 0.0 | 1.0 | |
cltr2_human | 308 | 7.56x56 | TM7 | A => V | missense | 1.715e-05 | 2 | 116642 | 0 | 0.09 | 0.059 | GP (contact) |
cltr2_human | 311 | 8.49x49 | H8 | N => K | missense | 8.635e-05 | 10 | 115802 | 0 | 0.0 | 1.0 | GP (contact) |
cltr2_human | 315 | 8.53x53 | H8 | R => K | missense | 0.002308 | 265 | 114804 | 2 | 0.18 | 0.036 | |
cltr2_human | 333 | C-term | V => F | missense | 9.067e-06 | 1 | 110290 | 0 | nan | 0.001 | ||
cltr2_human | 337 | C-term | S => N | missense | 9.104e-06 | 1 | 109844 | 0 | nan | 0.197 | ||
cltr2_human | 342 | C-term | K => N | missense | 9.161e-06 | 1 | 109154 | 0 | nan | 0.002 | ||
cltr2_human | 346 | C-term | V => A | missense | 9.262e-06 | 1 | 107972 | 0 | nan | 0.131 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue